Senegenin Attenuates Hepatic Ischemia-Reperfusion Induced Cognitive Dysfunction by Increasing Hippocampal NR2B Expression in Rats |
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| Authors: | Weibin Xie Yan Yang Xiaoping Gu Yaguo Zheng Yu-e Sun Ying Liang Jinhua Bo Zhengliang Ma |
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| Affiliation: | 1. Drum Tower Clinical College of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.; 2. Department of Anesthesiology, Affiliated Drum-Tower Hospital, Medical College of Nanjing University, Nanjing, Jiangsu Province, China.; Hôital Robert Debré, France, |
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| Abstract: | BackgroundThe root of Polygala tenuifolia, a traditional Chinese medicine, has been used to improve memory and intelligence, while the underlying mechanisms remain largely unknown. In this study, we investigated the protective effects of senegenin, an component of Polygala tenuifolia root extracts, on cognitive dysfunction induced by hepatic ischemia-reperfusion.Methodology/Principal FindingsInitially, we constructed a rat model of hepatic ischemia-reperfusion (HIR) and found that the memory retention ability of rats in the step-down and Y maze test was impaired after HIR, paralleled by a decrease of N-methyl-D-aspartate (NMDA) receptor NR2B subunit mRNA and protein expressions in hippocampus. Furthermore, we found that administration of senegenin by gavage attenuated HIR-induced cognitive impairment in a dose and time dependent manner, and its mechanisms might partly due to the increasing expression of NR2B in rat hippocampus.Conclusions/SignificanceCognitive dysfunction induced by HIR is associated with reduction of NR2B expression. Senegenin plays a neuroprotective role in HIR via increasing NR2B expression in rat hippocampus. These findings suggest that senegenin might be a potential agent for prevention and treatment of postoperative cognitive dysfunction (POCD) or other neurodegenerative diseases. |
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