Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice |
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| Authors: | Rie Mukai Hitomi Horikawa Yutaka Fujikura Tomoyuki Kawamura Hisao Nemoto Takeshi Nikawa Junji Terao |
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| Affiliation: | 1. Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.; 2. Department of Pharmaceutical Chemistry, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.; 3. Department of Nutritional Physiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.; Istituto di Ricerche Farmacologiche Mario Negri, Italy, |
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| Abstract: | Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake. |
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