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Ectoine Biosynthesis in Mycobacterium smegmatis |
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| Authors: | Naomi Ofer Marina Wishkautzan Michael Meijler Ying Wang Alexander Speer Michael Niederweis Eyal Gur |
| Affiliation: | aDepartment of Life Sciences;bThe National Institute for Biotechnology in the Negev;cDepartment of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel;dDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA |
| Abstract: | Mycobacterium smegmatis is a commonly used mycobacterial model system. Here, we show that M. smegmatis protects itself against elevated salinity by synthesizing ectoine and hydroxyectoine and characterize the phenotype of a nonproducing mutant. This is the first analysis of M. smegmatis halotolerance and of the molecular mechanism that supports it. |
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