Octamers and nanoparticles as hemoglobin based blood substitutes |
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Authors: | Baudin-Creuza Véronique Chauvierre Cédric Domingues Elisa Kiger Laurent Leclerc Liliane Vasseur Corinne Célier Chantal Marden Michael C |
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Affiliation: | Institut National de la Sante et de la Recherche Médicale, INSERM U779, University of Paris XI, 94275 Le Kremlin-Bicêtre, France. |
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Abstract: | Progress in developing a blood substitute is aided by new biotechnologies and a better understanding of the circulatory system. For Hb based solutions, there is still a debate over the best set of fundamental parameters concerning the oxygen affinity which is correlated with the oxidation rate, the cooperativity, the transporter size, and of course the final source of material. Genetic engineering methods have helped discover novel globins, but not yet the quantity necessary for the high demand of blood transfusions. The expanding database of globin properties has indicated that certain individual parameters are coupled, such as the oxygen affinity and the oxidation rate, indicating that one must accept a compromise of the best parameters. After a general introduction of these basic criteria, we will focus on two strategies concerning the size of the oxygen transporter: Hb octamers, and Hb integrated within a nanoparticle. |
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