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Relative content of isoaccepting tRNAs for glycine and proline in avian tendon cells with different rates of procollagen synthesis
Authors:Bouchra Ouenzar, Dominique Weill, Bernadette Agoutin, G  rard Keith,Th  r  se Heyman
Affiliation:Bouchra Ouenzar, Dominique Weill, Bernadette Agoutin, Gérard Keith,Thérèse Heyman
Abstract:The relative amounts of iso-tRNAsGly and iso-tRNAsPro existing in chick embryo tendon are indicative of a specialization of the tRNA population for collagen synthesis. These amounts are not modified (i) in primary avian tendon (PAT) cells in culture for which the procollagen production varies from about 10% of total protein synthesis to 60% and (ii) in tendons from immature chicks, which show a 3-fold decrease of procollagen production with increasing age. The characteristic tRNA pattern was not maintained in cells which had lost the ability to make high levels of collagen as observed in the cases of: (i) PAT cells reaching confluency; (ii) virus-transformed PAT cells and (iii) tendon from adult chick. Our data are consistent with the idea that tendon tRNA specialization for collagen synthesis is a differentiation feature independent of the expression level of the collagenic function but related to its maintenance.
Keywords:Procollagen synthesis   Isoaccepting tRNA   tRNA   Differentiation   Malignant transformation   (Chick tendon cell)
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