The biosynthesis of alkyl ether bonds in lipids by a cell-free system |
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| Authors: | F Snyder B Malone R L Wykle |
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| Affiliation: | 1. Università di Torino, Dipartimento di Scienze Agrarie, Forestali e Alimentari, Largo Paolo Braccini 2, 10095 Grugliasco, TO, Italy;2. Istituto di Enologia e Ingegneria Agro-Alimentare, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy;3. Industrie De Nora SpA, Via Bistolfi 35, 20134 Milano, MI, Italy;4. Université Bordeaux Segalen, Unité de recherche Oenologie, EA 4577, USC 1219 INRA, IPB, Faculté d''Oenologie, Institut des Sciences de la Vigne et du Vin, 210, Chemin de Leysotte, CS 50008, 33882 Villenave d''Ornon Cedex, France |
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| Abstract: | Investigators have found the biological significance and the biosynthetic pathways of ether-linked lipids containing glycerol difficult to determine (1). Despite available knowledge concerning enzymes for the biocleavage (2,3), deacylation (4), acylation (5,6), and phosphorylation (7) of glyceryl ethers, the biosynthesis of the ether bond in these compounds has not previously been demonstrated in a cell-free system.This note describes an active enzyme complex capable of converting intact l-14C-labeled fatty alcohols into alkyl glyceryl ethers. The reaction has been demonstrated in whole homogenates and in microsomal-plus-supernatant fractions of transplantable preputial tumors in mice. These tumors are typical of neoplasms containing high quantities of alkyl ether linkages in both neutral- and phospho-glycerides (8). |
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