| Abstract: | Three new withanolides ( 1 – 3 ), named as daturanolide A–C, along with six known withanolides ( 4 – 9 ) were isolated from the flowers of Datura metel L. Their structures with absolute configurations were elucidated by a series of spectroscopic methods, electronic circular dichroism (ECD) analyses, and X‐ray crystallography. All the isolates were evaluated for cytotoxicity against five human cancer cell lines (HCT116, U87‐MG, NCI‐H460, BGC823, and HepG2), and 6 exhibited marked cytotoxicity. |
