Brominated Diphenyl Ethers Including a New Tribromoiododiphenyl Ether from the Vietnamese Marine Sponge Arenosclera sp. and Their Antibacterial Activities |
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Authors: | Dae‐Won Ki Maurice Ducret Awouafack Chin Piow Wong Hien Minh Nguyen Quang Minh Thai Lien Huong TonNu Hiroyuki Morita |
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Institution: | Dae‐Won Ki,Maurice Ducret Awouafack,Chin Piow Wong,Hien Minh Nguyen,Quang Minh Thai,Lien Huong Ton?Nu,Hiroyuki Morita |
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Abstract: | A new tribromoiododiphenyl ether ( 1 ) and eight known brominated diphenyl ethers ( 2 – 9 ) were isolated from the MeOH extract of the sponge Arenosclera sp. collected in Vietnam, using repeated open column chromatography and preparative thin layer chromatography. The chemical structure of the new compound 1 was determined by analyses of spectroscopic (1D‐ and 2D‐NMR, and MS) data and by comparison of our data with those reported in the literature. Compounds 1 , 3 , and 8 exhibited strong antibacterial activities against the Gram‐positive bacteria Bacillus subtilis and Staphylococcus aureus and the Gram‐negative bacterium Klebsiella pneumoniae with MIC values ranging from 0.8 to 6.3 μm , while compounds 5 and 7 only displayed activities against Gram‐positive bacteria with MIC values from 0.5 to 3.1 μm . Compound 2 showed activities against the four tested bacteria with MIC values ranging from 0.5 to 6.3 μm . |
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Keywords: | Vietnam marine sponge Arenosclera tribromoiododiphenyl ether antibacterial activity biological activity |
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