Synthesis and Biological Activity of New 4‐tert‐Butylcyclohexanone Derivatives |
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Authors: | Agata Kozio Mateusz Jasnowski Ewa Grela Maryla Szczepanik Beata Gabry Katarzyna Dancewicz Stanisaw Lochyski |
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Institution: | Agata Kozio?,Mateusz Jasnowski,Ewa Grela,Maryla Szczepanik,Beata Gabry?,Katarzyna Dancewicz,Stanis?aw Lochyński |
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Abstract: | In the synthesis performed in this study, derivatives of 4‐tert‐butylcyclohexanone 1 were obtained using typical reactions of organic synthesis. The bioactivity of the selected compounds was evaluated. 1‐(Bromomethyl)‐8‐tert‐butyl‐2‐oxaspiro4.5]decan‐3‐one ( 5 ) was characterized by attractant properties against larvae and a weak feeding deterrent activity against adults of Alphitobius diaperinus Panzer . This bromolactone was a moderate antifeedant towards Myzus persicae Sulzer . In addition, ethyl (4‐tert‐butylcyclohexylidene)acetate ( 2 ) and bromolactone 5 displayed antibacterial activity. The strongest bacteriostatic effect was observed against Gram‐positive strains: Bacillus subtilis and Staphylococcus aureus. The bromolactone 5 also limited the growth of Escherichia coli strain. |
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Keywords: | 4-tert-butylcyclohexanone lactones bromolactones biological activity antibacterial activity |
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