Glycogenesis and lipogenesis from 14C-glucose in vivo in rats irradiated with fractionated doses of gamma rays

Irradiation with fractionated doses is a specific form of stress and the data concerning these problems are topical for recent radiobiology, radiology and oncology. Interest in this present paper is focused on tissue glycogenesis and lipogenesis from U-14C-glucose in vivo in rats irradiated with fractionated doses of 2.39 Gy once a week. Analyses were done after 1-6 fractions, up to total accumulated doses of 2.39, 4.78, 7.17, 9.76, 11.95 and 14.34 Gy, which means LD50/30 for this experimental model. Fractionated irradiation of rats led to glycogen deposition and increased incorporation of 14C-glucose into the liver, heart and skeletal muscles, but not into brain glycogen. The ascertained changes were not dose-dependent. 14C-glucose was incorporated into the liver and adipose tissue lipids to a small extent, and synthesis of liver cholesterol increased only after the 5th and 6th fractions. A decreased concentration of hepatic lipids, especially of cholesterol, was observed from the 3rd to the 6th fractions.