CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis |
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| Authors: | Soo-Hyun Chung Keisuke Seki Byung-Il Choi Keiko B Kimura Akihiko Ito Noriyuki Fujikado Shinobu Saijo Yoichiro Iwakura |
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| Institution: | (1) Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, 108-8639 Minato-ku, Tokyo, Japan;(2) Department of Anatomy, College of Medicine, Korea University, 126-1, 5-Ga, Anam-Dong, Sungbuk-Gu, Seoul, Korea;(3) Division of Molecular Pathology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, 108-8639 Minato-ku, Tokyo, Japan;(4) Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, 332-0012 Saitama, Japan |
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| Abstract: | Introduction Chemokines and their receptors are potential therapeutic targets in rheumatoid arthritis (RA). Among these, several studies
suggested the involvement of CXC chemokine 4 (CXCR4) and its ligand CXC ligand 12 (SDF-1) in RA pathogenesis. However, the
role of these molecules in T-cell function is not known completely because of embryonic lethality of Cxcr4- and Cxcl12- deficient mice. In this report, we generated T cell-specific Cxcr4 -deficient mice and showed that the CXCR4 in T cells is important for the development of collagen-induced arthritis (CIA). |
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