Early stress affects neurogenesis in the rat rostral migratory stream |
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Authors: | Email author" target="_blank">Kamila?LievajováEmail author Marcela?Marton?íková Juraj?Bla?ko Judita?Orendá?ová Viera?Alma?iová Enik??Ra?eková |
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Institution: | 1.Institute of Neurobiology,Slovak Academy of Sciences,Ko?ice,Slovak Republic;2.University of Veterinary Medicine,Ko?ice,Slovak Republic |
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Abstract: | Stressful experience during the early postnatal period may influence processes associated with neurogenesis (i.e. proliferation, cell death, appearance of astrocytes or cell differentiation) in the neonatal rat rostral migratory stream
(RMS). To induce stress, pups were subjected to maternal deprivation daily for three hours, starting from the first postnatal
day till the seventh postnatal day. Immunohistochemical methods were used to visualize proliferating cells and astrocytes;
dying cells and nitrergic cells were visualized using histochemical staining. Quantitative analysis showed that maternal deprivation
decreased the number of proliferating cells and significantly increased the number of dying cells in the RMS. Maternal deprivation
did not influence the appearance of astrocytes in the RMS, but caused premature differentiation of nitrergic cells. In control
rats, nitrergic cells can be observed in the RMS as early as the tenth postnatal day. In maternally deprived pups, these cells
were detected as early as the seventh postnatal day. The observed earlier appearance of nitrergic cells in the RMS was associated
with altered proliferation and increased cell dying and this observation supports the hypothesis that nitric oxide has an
anti-proliferative role in the RMS. Our study demonstrates that maternal deprivation represents a stressful condition with
a profound impact on early postnatal neurogenesis. |
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