Different functional classes of genes are characterized by different compositional properties |
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Authors: | D'Onofrio Giuseppe Ghosh Tapash Chandra Saccone Salvatore |
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Institution: | Laboratorio di Evoluzione Molecolare, Stazione Zoologica A. Dohrn, Villa Comunale, 80121 Napoli, Italy. donofrio@szn.it |
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Abstract: | A compositional analysis on a set of human genes classified in several functional classes was performed. We found out that the GC3, i.e. the GC level at the third codon positions, of the genes involved in cellular metabolism was significantly higher than those involved in information storage and processing. Analyses of human/Xenopus ortologous genes showed that: (i) the GC3 increment of the genes involved in cellular metabolism was significantly higher than those involved in information storage and processing; and (ii) a strong correlation between the GC3 and the corresponding GCi, i.e. the GC level of introns, was found in each functional class. The non-randomness of the GC increments favours the selective hypothesis of gene/genome evolution. |
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Keywords: | Base composition (GC) Biased gene conversion (BGC) Chromosomal band Codon usage Intron Isochore |
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