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Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response
Institution:1. Université Claude Bernard Lyon 1 – Laboratoire de Biologie Tissulaire et d''Ingénierie Thérapeutique, UMR 5305, Université Lyon 1, CNRS, IBCP, Lyon, France;1. Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium;2. Cytokine Receptor Laboratory, Department of Biochemistry, Ghent University, Ghent, Belgium;1. Department of Biomedical Molecular Biology, Laboratory Molecular Immunology, Ghent University, Ghent, Belgium;2. Department of Biomedical Sciences, Virology Unit, Institute of Tropical Medicine, Antwerp, Belgium;3. Department of Biochemistry, Cytokine Receptor Lab, Ghent University, Ghent, Belgium;4. Medical Biotechnology, VIB, Ghent, Belgium;5. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium;6. Faculty of Veterinary Medicine, Laboratory of Gene Therapy, Ghent University, Ghent, Belgium;7. Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany;8. Centre for Experimental and Clinical Infection Research, Institute for Experimental Infection Research, TWINCORE, Hannover, Germany;9. Institute of Immunology, Medical School Hannover, Hannover, Germany;10. Department of Molecular Immunology, Helmholtz Centre for infection Research, Braunschweig, Germany;11. Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium;1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA;2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA;3. Department of Anesthesiology, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA;4. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;5. Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China;2. School of Medicine, Tsinghua University, Beijing 100084, China;3. State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China;4. Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, China;5. Suzhou Abogen Biosciences Co., Ltd., Suzhou 215123, China
Abstract:
Keywords:mRNA vaccines  mRNA design  innate immunity  adaptive immunity
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