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Differential of sex steroids of prostaglandin secretion by male and female cultured piglet endothelial cells
Authors:C Seillan  C Ody  F Russo-Marie  D Duval
Institution:3. INSERM U 7, Hopital Necker, 161 Rue de Sèvres 75015 Paris, France
Abstract:The effect of sex steroids, 17β-estradiol and testosterone, on the production of 6-keto-prostaglandin F, prostaglandin F and prostaglandin E2 was studied in cultures of piglet aorta endothelial cells. In cells isolated from female animals both steroids stimulated the secretion of prostaglandins. In contrast, sex steroids did not affect prostaglandin synthesis by endothelial cells taken from male animals. In addition, female endothelial cells convert testosterone into Estriol, estrone and estradiol. estradiol-induced stimulation of prostacyclin production may explain in part the beneficial role generally attributed to naturally occuring estrogens in cardiovascular diseases.
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