Secretogogue responses of leukotriene C4, D4: Comparison of potency in canine trachea <math><mtext>in</mtext></math><math><mtext>vivo</mtext></math>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Secretogogue responses of leukotriene C₄, D₄: Comparison of potency in canine trachea $in$ $vivo$

Authors:	Herbert G Johnson Martha L McNee

Institution:	Hypersensitivity Diseases Research The Upjohn Company 301 Henrietta Street Kalamazoo, Michigan 49001, USA

Abstract:	By the use of close arterial injection of leukotrienes into the circulation supplying the upper cervical canine trachea, it has been possible to assess the secretogogue effects of leukotriene C₄, and D₄ on mucus secretion. Both LTC₄ and LTD₄ increased mucus secretion over baseline levels by a statistically significant level (p = < 0.05). LTD₄ was more potent than C₄ with relative potencies of 2500, 320, 630, and 500 based on hillock formation (a measure of secretion) at 1, 2, 3, and 4 minutes after injection. The overall difference in potency in this animal model of mucus production was LTD₄ > C₄ by 1000-fold.

Keywords:
本文献已被 ScienceDirect 等数据库收录！