The effect of PGF2a on in vivo cerebral arteriolar diameter in cats and rats |
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Authors: | Earl F Ellis Enoch P Wei Carolyn S Cockrell Sung Choi Hermes A Kontos |
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Institution: | Departments of Pharmacology and Medicine, Medical College of Virginia, Virginia Commonwealth University, Box 613 - MCV Station, Richmond, Virginia 23298 USA |
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Abstract: | We compared the effect of tropical application of PGF2a on cerebral arterioles in cats and rats equipped with an acutely implanted cranial window. Arterial diameter was measured using a microscope and image splitting device. PGF2a in a concentration ranging from 10?7 to 10?5 M had no effect on large (≥ 100 μm) or small (< 100 μm) cat pial arterioles, but induced a dose dependent constriction of rat pial arterioles with a maximum constriction fo 76% of control diameter. Dilation of cat large cerebral arterioles by topically applied PGE2 was not affected by simultaneous application of PGF2a and PGE2 induced dilation of small arterioles was decreased 3% by PGF2a. While we and others have previosuly shown that both cat and rat brain can synthesize PGF2a, it appears that PGF2a is not likely to normally be a major modulator of cerebral arteriolar resistance in all species. |
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Keywords: | To whom all correspondence should be addressed |
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