The distribution pattern of critically short telomeres in human osteoarthritic knees |
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| Authors: | Maria Harbo Laila Bendix Anne-Christine Bay-Jensen Jesper Graakjaer Kent Søe Thomas L Andersen Per Kjaersgaard-Andersen Steen Koelvraa Jean-Marie Delaisse |
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| Affiliation: | (1) Department of Clinical Cell Biology, Vejle/Lillebaelt Hospital, Institute of Regional Health Research, University of Southern Denmark, Kabbeltoft 25, 7100 Vejle, Denmark;(2) Department of Clinical Genetics, Vejle/Lillebaelt Hospital, Institute of Regional Health Research, University of Southern Denmark, Kabbeltoft 25, 7100 Vejle, Denmark;(3) Department of Orthopedic Surgery, Vejle/Lillebaelt Hospital, Institute of Regional Health Research, University of Southern Denmark, Kabbeltoft 25, 7100 Vejle, Denmark;(4) Danish Aging Research Center, University of Southern Denmark, J.B. Winsloews Vej 9B, 5000 Odense C, Denmark |
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| Abstract: | Introduction Telomere shortening is associated with a number of common age-related diseases. A role of telomere shortening in osteoarthritis (OA) has been suggested, mainly based on the assessment of mean telomere length in ex vivo expanded chondrocytes. We addressed this role directly in vivo by using a newly developed assay, which measures specifically the load of ultra-short single telomeres (below 1,500 base pairs), that is, the telomere subpopulation believed to promote cellular senescence. |
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