Long-acting contraceptive agents: Aliphatic and alicyclic carboxylic esters of levonorgestrel |
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| Authors: | A. Shafiee M. Vossoghi F. Savabi T.G. Watson K. Schubert K. Ponsold W. Werner H. Wagner R. Vlahov V. Tarpanov M. Boshkova-Ljapova B. Milenkov V. Stoilova J. Vlahov G. Snatzke H. Duddeck |
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| Affiliation: | 2. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria;1. Lehrstuhl fur Structurchemie, Ruhr Universitat Bochum, 4630 Bochum 1, (F.D.R.) Bulgaria |
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| Abstract: | Esters of levonorgestrel (13β-ethyl-17α-ethynyl-17β-hydroxygon-4-en -3-one) with a variety of aliphatic and alicyclic carboxylic acids have been prepared and characterised. In tests for the suppression of estrus in rats, esters with short-chain aliphatic acids and with cyclobutane-carboxylic acid were considerably more active than the standard, norethisterone enanthate (17α-ethynyl-17β-hydroxyestr-4-en-3-one). Such esters show great promise for development as long-acting progestogens. |
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