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Dynamic Ligand Discrimination in the Notch Signaling Pathway
Authors:Nagarajan Nandagopal  Leah A Santat  Lauren LeBon  David Sprinzak  Marianne E Bronner  Michael B Elowitz
Institution:1. Howard Hughes Medical Institute and Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA;2. Calico Life Sciences, 1170 Veterans Boulevard, South San Francisco, CA 94080, USA;3. Department of Biochemistry and Molecular Biology, Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel;4. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA;5. Howard Hughes Medical Institute, Division of Biology and Biological Engineering, Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA
Abstract:
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  • Keywords:systems biology  Notch pathway  intercellular signaling  ligand multiplicity  single cell dynamics  signaling dynamics  signal encoding  signal decoding  myogenesis
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