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In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment
Authors:Qiang Guo  Carina Lehmer  Antonio Martínez-Sánchez  Till Rudack  Florian Beck  Hannelore Hartmann  Manuela Pérez-Berlanga  Frédéric Frottin  Mark S Hipp  F Ulrich Hartl  Dieter Edbauer  Wolfgang Baumeister  Rubén Fernández-Busnadiego
Institution:1. Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;2. German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany;3. Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany;4. Department of Biophysics, Ruhr University Bochum, 44780 Bochum, Germany;5. NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA;6. Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;7. Ludwig-Maximilians University Munich, 81377 Munich, Germany
Abstract:
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  • Keywords:ALS  FTD  dipeptide-repeat proteins  UPS  cryoelectron microscopy  cryo-EM  cryo-ET  cryo-FIB
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