Human platelet aggregation induced by prostaglandin endodisulfide |
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| Authors: | Minoru Okuma Tanihiro Yoshimoto Shozo Yamamoto |
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| Institution: | 1. Department of Internal Medicine, Kyoto University Faculty of Medicine, Kyoto, Japan;2. Department of Medical Chemistry Kyoto University Faculty of Medicine, Kyoto, Japan |
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| Abstract: | The effect of human platelet functions of 9,11-dithio analogues of prostaglandin endoperoxide was investigated. Methyl (5z,9α,11α,13e,15S)-9,11-epidithio-15-hydroxyprosta- 5,13-dienoate induced platelet aggregation, while the 9β,11β-epimer was inactive. The platelet aggregation caused by the 9α,11α-dithio analogue was associated with serotonin release from platelets, and was inhibited by methyl ester of prostaglandin I2 (prostacyclin) but not by indomethacin. |
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