Modulation of human platelet adenylate cyclase by prostacyclin (PGX) |
| |
Authors: | R.R. Gorman S. Bunting O.V. Miller |
| |
Affiliation: | Department of Experimental Biology The Upjohn Company Kalamazoo, MI 49001 USA |
| |
Abstract: | Prostacyclin (PGX) ( has been found to be a potent stimulator of cAMP accumulation in human platelet rich plasma (PRP), and a direct stimulator of platelet microsome adenylate cyclase. Prostacyclin is, on a molar basis, at least 10 times more potent a stimulator of cAMP accumulation in platelets than PGE1. The prostacyclin stimulation of platelet cAMP accumulation can be antagonized by the prostaglandin endoperoxide PGH2, and a PGH2-induced platelet aggregation is antagonized by prostacyclin. A model of platelet homeostasis is proposed that suggests platelet aggregation is controlled by a balance between the adenylate cyclase stimulating activity of prostacyclin, and the cAMP lowering activity of PGH2. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|