PGE2 and PGF2α biosynthesis in stimulated and nonstimulated peritoneal preparations containing macrophages |
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Authors: | Alam Farzad Neal S Penneys Abdul Ghaffar Vincent A Ziboh Jean Schlossberg |
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Institution: | Department of Dermatology, Microbiology and Biochemistry University of Miami School of Medicine, Miami, FL 33152, USA |
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Abstract: | The biosynthesis of PGE2 and PGF2α was measured in intact peritoneal exudate preparations obtained fom -treated and control C3H mice. Although both the control and stimulated preparations biosynthesized PGF2α and PGE2 from 1–14C] arachidonic acid, the stimulated preparations generated more of both prostaglandins than did nonstimulated preparations, probably as a result of increased synthesis within macrophages. Increased transformation of PGE2 into PGF2α 9-ketoreductase was noted in stimulated preparations when compared to that in control cells. The data suggest that stimulated macrophages are capable of generating increased quantities of PGF2α and therefore might function as one source of this substance in resolving inflammatory reactions. |
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