Non-specific prostaglandin antagonism by 8-ethoxycarbonyl-5-methyl-10, 11-dihydro-PGA<sub>1</sub>-ethyl ester (HR 546) on some smooth muscle preparations <span class="math"><math><mtext>in vitro</mtext></math></span>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Non-specific prostaglandin antagonism by 8-ethoxycarbonyl-5-methyl-10, 11-dihydro-PGA₁-ethyl ester (HR 546) on some smooth muscle preparations $in vitro$

Authors:	P.G. Adaikan S.M.M. Kartin

Affiliation:	Department of Obstetrics and Gynaecology, University of Singapore, Kandang Kerbau Hospital, Singapore 8

Abstract:	The ability of 8-ethoxycarbonyl-10, 11 dihydro-A-prostaglandin(HR 546) to antagonise smooth muscle contracting effect of prostaglandins E₂ and F_2α on isolated preparations of rat and hamster stomach fundus, guinea pig ileum and gerbil colon has been studied. HR 546 was found to be a potent, non-specific, probably competitive, prostaglandin antagonis on these four smooth muscle preparations.

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