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Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease
Authors:Md Fakruddin  Fan-Yan Wei  Takeo Suzuki  Kana Asano  Takashi Kaieda  Akiko Omori  Ryoma Izumi  Atsushi Fujimura  Taku Kaitsuka  Keishi Miyata  Kimi Araki  Yuichi Oike  Luca Scorrano  Tsutomu Suzuki  Kazuhito Tomizawa
Affiliation:1. Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan;2. Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan;3. Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, Tokyo 113-8656, Japan;4. Department of Biology, University of Padova, Padova 35121, Italy;5. Institute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-8556, Japan;6. Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Kawaguchi, Japan
Abstract:
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  • Keywords:tRNA  modification  taurine  mitochondria  Opa1
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