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Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat
Authors:Shiki Okamoto  Tatsuya Sato  Michihiro Tateyama  Haruaki Kageyama  Yuko Maejima  Masanori Nakata  Satoshi Hirako  Takashi Matsuo  Sanda Kyaw  Tetsuya Shiuchi  Chitoku Toda  Udval Sedbazar  Kumiko Saito  Nur Farehan Asgar  Boyang Zhang  Shigefumi Yokota  Kenta Kobayashi  Fabienne Foufelle  Yasuhiko Minokoshi
Affiliation:1. Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan;2. Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan;3. Second Department of Internal Medicine (Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology), Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami-gun, Okinawa 903-0215, Japan;4. Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan;5. Department of Nutrition, Faculty of Health Care, Kiryu University, 606-7 Kasakake-cho Azami, Midori, Gunma 379-2392, Japan;6. Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan;7. Department of Health and Nutrition, University of Human Arts and Sciences, 1288 Magome, Iwatsuki-ku, Saitama-shi, Saitama 339-8539, Japan;8. Division of Neurology, Respirology, Endocrinology, and Metabolism, Department of Internal Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan;9. Department of Physiology, University of Medicine 1, Yangon, Myanmar;10. Section of Viral Vector Development, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan;11. Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France;12. INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France;13. Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France;14. Division of Peptide Drug Innovation, Global Research Center for Innovative Life Science, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan;15. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Abstract:
Keywords:food preference  AMPK  CRH  PVH  CPT1c
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