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Loss of an Androgen-Inactivating and Isoform-Specific HSD17B4 Splice Form Enables Emergence of Castration-Resistant Prostate Cancer
Authors:Hyun-Kyung Ko  Michael Berk  Yoon-Mi Chung  Belinda Willard  Rohan Bareja  Mark Rubin  Andrea Sboner  Nima Sharifi
Institution:1. Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA;2. Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA;3. Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA;4. Research Core Services, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA;5. Institute for Precision Medicine, Weill-Cornell Medical Center, New York, NY 10065, USA
Abstract:
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  • Keywords:prostate cancer  metabolism  androgens  androgen receptor  steroids  enzymes  drug resistance  HSD17B4  oncology  splicing
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