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Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
Authors:Le-Ann Hwang  Beng Hooi Phang  Oi Wah Liew  Jabed Iqbal  Xiao Hui Koh  Xin Yu Koh  Rashidah Othman  Yuezhen Xue  A. Mark Richards  David P. Lane  Kanaga Sabapathy
Affiliation:2. Division of Cellular & Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore 169610, Singapore;3. Cardiovascular Research Institute, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health Systems, Singapore 119228, Singapore;4. Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore;5. Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore;6. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore;7. Institute of Molecular & Cellular Biology, Singapore 138673, Singapore
Abstract:
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  • Keywords:amino acid-specific antibody  diagnosis  hotspot mutations  mAbs  mutation specific  p53  precision medicine  therapeutic antibody  tumor suppressor
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