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Biological activity of some schiff bases and their metal complexes |
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| Authors: | R. K. Parashar R. C. Sharma Govind Mohan |
| Affiliation: | 1. Department of Chemistry, Agra University, Agra, India 2. Department of Pharmacology, S. N. Medical College, Agra, India |
| Abstract: | Schiff bases derived from salicylaldehyde and 2-substituted aniline and their metal chelates with Cu(II), Ni(II), and Co(II) ions were synthesized and screened for the antiinflammatory and antiulcer activity. The compound salicylidene anthranilic acid (SAA) was found to possess the antiinflammatory and antiulcer activity. The copper complexes showed an increased antiulcer activity. The SAA is perhaps acting by influencing prostaglandin biosynthesis. |
| Keywords: | KeywordHeading" >Index Entries Schiff bases metal chelates NSAID antiulcer activity substituted anilines prostaglandins |
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