Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition. |
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| Authors: | B Boyer and R Odessey |
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| Affiliation: | Louisiana State University Medical Center, Department of Physiology, New Orleans 70112. |
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| Abstract: | The potential for branched-chain 2-oxo acid dehydrogenase complex (BCOADC) activity to be controlled by feedback inhibition was investigated by calculating the Elasticity Coefficients for several feedback inhibitors. We suggest that feedback inhibition is a quantitatively important regulatory mechanism by which branched-chain 2-oxo acid dehydrogenase activity is regulated. The potential for control of enzyme activity is greater for NADH than for the acyl-CoA products, and suggests that factors that alter the redox potential may physiologically regulate BCOADC activity through a feedback inhibitory mechanism in vivo. Local pH may also be an important regulatory control factor. |
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