| 新的凋亡抑制因子Survivin的研究进展 |
| |
| 引用本文： | 闵玲,周克元.新的凋亡抑制因子Survivin的研究进展[J].生物化学与生物物理进展,2002,29(3):339-341. |
| |
| 作者姓名： | 闵玲 周克元 |
| |
| 作者单位： | 广东医学院生物化学与分子生物学研究所,湛江,524023 |
| |
| 摘 要： | Survivin是近年来发现的一种凋亡抑制因子，属于凋亡抑制蛋白（inhibitor of apoptosis proteins,IAP）家族的新成员；主要通过抑制caspase-3和caspase-7的活性而阻断细胞凋亡过程. Survivin选择性地表达于胚胎发育组织和大多数肿瘤组织，而正常成人终末分化组织中不表达. Survivin参与了细胞周期调控，与肿瘤的发生、发展和预后密切相关，可作为肿瘤治疗的新靶点.
|
| 关 键 词： | survivin，细胞凋亡，肿瘤，凋亡抑制蛋白 |
| 收稿时间： | 2001/12/14 0:00:00 |
| 修稿时间： | 3/6/2002 12:00:00 AM |
Recent Advances in a Novel Anti-apoptosis Factor: Survivin |
| |
| MIN Ling and ZHOU Ke-Yuan.Recent Advances in a Novel Anti-apoptosis Factor: Survivin[J].Progress In Biochemistry and Biophysics,2002,29(3):339-341. |
| |
| Authors: | MIN Ling and ZHOU Ke-Yuan |
| |
| Institution: | Institute of Biochemistry, Guangdong Medical College, Zhanjiang 524023, China;Institute of Biochemistry, Guangdong Medical College, Zhanjiang 524023, China |
| |
| Abstract: | Survivin is a recently identified member of the inhibitor of apoptosis protein (IAP)family, which inhibits processing of downstream effector caspase-3 and caspase-7 in cell receiving apoptotic stimulus. Unlike other IAP protein, found during embryonic and fetal development, survivin was completely down-regulated and undetectable in normal adult tissues, and became prominently reexpressed in all of the most common cancers. Survivin plays important pole in regulation of cell cycle. Its expression in tumors has been associated with increased aggressiveness, recurrence and decreased patient survival. Survivin may be a new target for cancer therapy. |
| |
| Keywords: | survivin apoptosis tumor inhibitor of apoptosis protein (IAP) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
