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Inositol phosphates: a remarkably versatile enzyme
Authors:Michell Robert H
Institution:School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK. r.h.michell@bham.ac.uk
Abstract:Ins(3,4,5,6)P(4) is an inhibitor of Ca(2+)-activated Cl(-) channels, but further understanding has been hindered by ignorance of how it is made in cells. It now transpires that one protein with ATP-dependent kinase and phosphatase activities interconverts Ins(3,4,5,6)P(4) and Ins(1,3,4,5,6)P(5), as well as several other inositol polyphosphates.
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