Inositol phosphates: a remarkably versatile enzyme |
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Authors: | Michell Robert H |
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Institution: | School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK. r.h.michell@bham.ac.uk |
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Abstract: | Ins(3,4,5,6)P(4) is an inhibitor of Ca(2+)-activated Cl(-) channels, but further understanding has been hindered by ignorance of how it is made in cells. It now transpires that one protein with ATP-dependent kinase and phosphatase activities interconverts Ins(3,4,5,6)P(4) and Ins(1,3,4,5,6)P(5), as well as several other inositol polyphosphates. |
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