The dirhodium-method in the determination of absolute configurations of phospholene chalcogenides |
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Authors: | Moeller Stefan Drzazga Zbigniew Pakulski Zbigniew Pietrusiewicz K Michał Duddeck Helmut |
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Affiliation: | Universit?t Hannover, Institut für Organische Chemie, Hannover, Germany. |
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Abstract: | The 1H, 13C, and 31P NMR signals of six chiral phospholene chalcogenides (X = O, S, Se) are duplicated in the presence of one mole equivalent of the chiral auxiliary Rh2[(R)-MTPA]4 (diastereomeric dispersion Deltanu; in Hz). The samples were investigated as nonracemic mixtures of enantiomers with known absolute configurations so that signs can be attributed to the Deltanu-values and each signal set can be assigned to the respective enantiomer. The signs are uniform--in particular those of 1H nuclei--and nearly independent of the nature of the chalcogen atom. Thus, if the absolute configuration of one compound is known, it is possible to derive absolute configurations in the whole series (correlation method). |
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Keywords: | phospholene chalcogenides absolute configuration diastereomeric dirhodium adducts NMR spectroscopy chiral auxiliary |
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