A low protein-high carbohydrate diet decreases D2 dopamine receptor density in rat brain. |
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Authors: | A Hamdi E S Onaivi C Prasad |
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Institution: | Laboratory of Neurosciences, Pennington Biomedical Research Center, Baton Rouge, LA 70808. |
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Abstract: | The property of D2 dopamine receptors in the rat brain was evaluated after long-term dietary manipulation. Groups of rats were pair-fed with equicaloric diet containing low protein (8%)-high carbohydrate, high protein (52%)-low carbohydrate and normal protein (20%) for 36 weeks. The low protein-high carbohydrate fed rats exhibited a significant decrease in the density (Bmax) of D2 dopamine receptor in the striatum (28%) and the mesolimbic regions (36%) with no apparent change in the receptor affinity (Kd). These findings suggest that long-term consumption of a low protein-high carbohydrate diet, by decreasing D2 dopamine receptor density, may be an important determinant of central dopaminergic function. |
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