Genetics of mitochondrial glutamate-oxaloacetate transaminase (GOT-2) in Tigriopus californicus |
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Authors: | Dill Mary M Burton Ronald S |
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Institution: | (1) Genetics Graduate Group, University of Pennsylvania, 19104 Philadelphia, Pennsylvania;(2) Department of Biology, University of Pennsylvania, 19104 Philadelphia, Pennsylvania |
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Abstract: | Glutamate-oxaloacetate transaminase (GOT; EC 2.6.1.1) occurs as two electrophoretically distinguishable isozymes in the copepod Tigriopus californicus. The slower-migrating form, referred to as GOT2, is shown to be associated with the mitochondrial cell fraction. GOT2 phenotypes are inherited in typical Mendelian fashion, indicating that they are encoded by a nuclear gene. Allelic frequencies for electrophoretic variants of the two Got loci in 12 California populations of T. californicus show a sharp differentiation of local populations. Linkage studies demonstrated that Got-2 is linked to Got-1; a map of four loci in linkage group I is presented.This work was supported by NSF grant DEB-8207000 to R.S.B. and an NIH traineeship in Genetics to M.M.D. |
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Keywords: | glutamate-oxaloacetate transaminase isozymes Tigriopus californicus population differentiation |
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