Decavanadate acts like an alpha-adrenergic agonist in redistributing protein kinase C activity |
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Authors: | S Gullapalli C K Kurup T Ramasarma |
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Affiliation: | Department of Biochemistry, Indian Institute of Science, Bangalore. |
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Abstract: | Perfusion of rat livers with polyvanadate, but not metavanadate, was found to increase in plasma membrane and decrease in cytosol protein kinase C activity, similar to that obtained with phenylephrine, an alpha-adrenergic agonist. The effect was prevented by phenoxybenzamine, but not by propranolol implicating alpha-adrenergic receptor activation. Comparison of crystal structures of decavanadate and nonadrenaline revealed the occurrence of a structural feature of O-O-O(N) with distances of 5.5 A and 2.9 A. |
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