Linkage and recombination between fragile X-linked mental retardation and the factor IX gene |
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Authors: | Stephen T Warren Thomas W Glover Richard L Davidson Pudur Jagadeeswaran |
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Institution: | (1) Center for Genetics, University of Illinois College of Medicine, 60612 Chicago, IL, USA;(2) The Genetics Center of the Southwest Biomedical Research Institute, 85281 Tempe, AZ, USA |
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Abstract: | Summary Linkage analysis on a family with fragile X-linked mental retardation was performed using a Taq 1 restriction fragment length polymorphism detected by a cloned human coagulation factor IX cDNA. Two affected brothers in this sibship were found to have different factor IX RFLP alleles, indicating a recombinational event occurred between the two genes. Our data therefore indicate that the gene responsible for fragile X-linked mental retardation is not as tightly linked to the factor IX gene as the previously published data may suggest. |
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