Inhibitors of phenylalanine ammonia-lyase: substituted derivatives of 2-aminoindane-2-phosphonic acid and 1-aminobenzylphosphonic acid |
| |
| Authors: | Miziak Piotr Zoń Jerzy Amrhein Nikolaus Gancarz Roman |
| |
| Institution: | Faculty of Chemistry, Department of Medicinal Chemistry and Microbiology, Wroc?aw University of Technology, Wybrzeze Wyspiańskiego 27, 50-370 Wroc?aw, Poland. |
| |
| Abstract: | Six derivatives of 2-aminoindane-2-phosphonic acid and 1-aminobenzylphosphonic acid were synthesized. The compounds were tested both as inhibitors of buckwheat phenylalanine ammonia-lyase (in vitro) and as inhibitors of anthocyanin biosynthesis (in vivo). (+/-)-2-Amino-4-bromoindane-2-phosphonic acid was found to be the strongest inhibitor from investigated compounds. The results obtained are a basis for design of phenylalanine ammonia-lyase inhibitors useful in the enzyme structure studies in photo labelling experiments. |
| |
| Keywords: | Phenylalanine ammonia-lyase Inhibitor 2-Aminoindane-2-phosphonic acid 2-Amino-4-bromoindane-2-phosphonic acid (+)-1-Amino-3′ 4′-dichlorobenzylphosphonic acid |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
