Behavioral comparisons of the stereoisomers of tetrahydrocannabinols |
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Authors: | B R Martin R L Balster R K Razdan L S Harris W L Dewey |
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Institution: | Department of Pharmacology, Medical College of Virginia Virginia Commonwealth University, Richmond, Virginia 23298, USA |
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Abstract: | The potencies of (?)--Δ9-THC, (+)--Δ9-THC, (+)--Δ9-THC, (?)--Δ8-THC and (+)--Δ8-THC were compared in several different species. (?)--Δ9-THC was 100 times more potent than (+)--Δ9-THC in depressing schedule-controlled responding in monkeys. The (+)- isomers were less effective than their corresponding (?)- isomers in the dog static-ataxia test, but potency ratios could not be determined due to a lack of dose-responsiveness of the (+)- isomers. However, it appeared that their potency differed by at least ten fold. The potency of (+)--Δ9-THC in the dog static-ataxia test was comparable to that of (+)--Δ9-THC. The hypothermia in mice produced by the (?) isomers of -Δ9-THC and -Δ8-THC were 9.1 and 30.4 times greater than that produced by their respective (+)-isomers. Also, the potency ratio of the (+)- and (?)--Δ9-THC was 5.6 as measured by depression of spontaneous activity in mice. The magnitude of the potency ratios of the THC stereo-isomers is dependent upon the species and the pharmacological test used. |
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