New purine derivatives for efficient preparation of nucleoside analogs via alkylation |
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| Authors: | Lukin K A Yang C X Bellettini J R Narayanan B A |
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| Affiliation: | Process Development, Chemical and Agricultural Products Division, Abbott Laboratories, North Chicago, IL 60064-6291, USA. |
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| Abstract: | New diazabicycloundecenium and phosphazenium derivatives of purines are introduced for mild and efficient preparation of nucleoside analogs via in situ alkylation. Diazabicycloundecenium salts of purines were obtained directly as a result of an unusual reaction between two corresponding amino compounds. |
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