Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication. |
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| Authors: | M J Slater R Baxter R W Bonser S Cockerill K Gohil N Parry E Robinson R Randall C Yeates W Snowden A Walters |
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| Affiliation: | GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, SG1 2NY, Stevenage, UK. mjs40312@glaxowellcome.co.uk |
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| Abstract: | The synthesis and antiviral evaluation of unsymmetrical indolocarbazole derivatives of Arcyriaflavin A, substituted with a range of alkyl groups at the indole nitrogen, is described. Structure-activity relationships in this series against human cytomegalovirus (HCMV) replication in cell culture are reported. Compound 4b was identified as potent inhibitor of HCMV (IC(50)=19 nM), which retained activity against a range of HCMV strains including ganciclovir resistant isolates. |
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