Transfer factor immunotherapy of recurrent non-infiltrative papillary bladder tumours

Summary The effect of transfer factor (TF) immunotherapy on recurrent papillary bladder tumours (grade 0 papilloma and grade 1 and grade 2 carcinoma) has been studied. In a double blind study 27 patients received either TF derived from nonimmune normal donors or physiological saline. The follow-up period was 1 year. There was no difference between the two treatment groups with regard to clinical responses. Circulating immune complexes and responses to various skin test antigens were also analysed. Responses to skin test antigens and the level of circulating immune complexes did not correlate with clinical status, and TF had no effect on these parameters.