| 大鼠生后发育期间胰腺IAPP免疫组织化学定位研究 |
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| 引用本文： | 黄岩,李占淳,石爱荣,崔铮. 大鼠生后发育期间胰腺IAPP免疫组织化学定位研究[J]. 中国组织化学与细胞化学杂志, 1994, 0(3) |
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| 作者姓名： | 黄岩 李占淳 石爱荣 崔铮 |
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| 作者单位： | 北京医科大学组织学与胚胎学系 |
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| 摘 要： | 本文应用免疫组织化学ＰＡＰ法对正常雄性Ｗｉｓｔａｒ大鼠生后发育期间胰腺ＩＡＰＰ－ＩＲ阳性细胞进行了定位研究。结果表明；生后１天的大鼠胰岛内即已存在ＩＡＰＰ－ＩＲ阳性细胞，双染法证实ＩＡＰＰ与胰岛素共存于胰岛Ｂ细胞的胞质内。ＩＡＰＰ细胞免疫反应强度随生后发育而变化，２８天以后趋于稳定。胰腺外分泌部也有散在的ＩＡＰＰ－ＩＲ细胞。本文初步探讨了上述结果的生物学意义。
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| 关 键 词： | IAPP胰腺，免疫组织化学，生后发育，大鼠 |
STUDIES ON IMMUNOHISTOCHEMICAL LOCALIZATION OF RAT ANCREATIC IAPP DURING POSTNATAL DEVELOPMENT |
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| Huang Yan, Li Zhanchun, Shi Airong, Cul Zheng. STUDIES ON IMMUNOHISTOCHEMICAL LOCALIZATION OF RAT ANCREATIC IAPP DURING POSTNATAL DEVELOPMENT[J]. Chinese Journal of Histochemistry and Cytochemistry, 1994, 0(3) |
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| Authors: | Huang Yan Li Zhanchun Shi Airong Cul Zheng |
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| Abstract: | The localization of pancreatic IAPP immunoreactive cells of male wistar rats duringpostnatal development was studied with immunohistochemical .PAP method. The results revealed that there were IAPP immunoreactive cells in islets of rats on the first day after birth.PAP double-staining for IAPP and insulin on the same section demostrated that IAPP waslocated in the cytoplasm of B cells. The morphology and immunoreactive intensity werechanging with postnatal development and tended to be stable on the 28th day after birth. Wealso found the scattered IAPP immunoreactive cells in exocrine pancreas. The biological significance of the above results was discussed. |
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| Keywords: | IAPP Pancreas Immunohistochemistry Postnatal development Rat |
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