Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium |
| |
Authors: | Locovei Silviu Wang Junjie Dahl Gerhard |
| |
Institution: | Department of Physiology and Biophysics, University of Miami, School of Medicine, P.O. Box 016430, 1600 NW 10th Avenue, Miami, FL 33136, USA. |
| |
Abstract: | The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP-induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves. |
| |
Keywords: | Pannexin Purinergic receptor Activation by calcium ATP-induced ATP release Calcium wave |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|