Karyotype evolution in the bone marrow of a patient with Fanconi anemia: breakpoints in clonal anomalies of this disease |
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| Authors: | J L Huret J Tanzer F Guilhot C Frocrain-Herchkovitch J R Savage |
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| Institution: | Departement de Hématologie et Oncologie Médicale, H?pital Jean Bernard, Poitiers, France. |
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| Abstract: | A 21-year-old Fanconi anemia patient developed refractory anemia. Laboratory studies revealed a transitory increased platelet count and a typical del(5q). Bone marrow karyotyping showed a -6, +der(6)t(1;6)(q12;p25) rearrangement and, two years later, a mosaic -6, +der(6),t(1:6)(q12;p25)/-2, +der 2), t(1;2)(q12;q37) constitution. The chromosome mechanism operating in this patient is discussed. |
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