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Bioconversion of Hydrocortisone by Cyanobacterium Fischerella ambigua PTCC 1635 |
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| Authors: | Mojtaba Tabatabaei Yazdi Younes Ghasemi Abdollah Ghasemian Shadman Shokravi Hossein Niknahad Mohsen Amini Ali Dehshahri Mohammad Ali Faramarzi |
| Institution: | (1) Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, 14174 Tehran, Iran;(2) Department of Biology, Institute of Applied Sciences, Iranian Center of Culture and Education, Shahid Beheshti University, P.O. Box 19835-371, Tehran, Iran;(3) Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shiraz University of Medical Sciences, P.O. Box 71345-1583, Shiraz, Iran;(4) Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, 14174 Tehran, Iran |
| Abstract: | Summary The bioconversion of hydrocortisone by a locally isolated strain of cyanobacterium Fischerella ambigua PTCC 1635 was investigated. Fischerella ambigua had not been previously examined for this potential. The fermentation led to production of 11β,17α, 20β, 21-tetrahydroxypregn-4-en-3-one and 11β-hydroxyandrost-4-en-3,17-dione. The metabolites were isolated and purified by chromatographic methods and identified using instrumental analyses. |
| Keywords: | Bioconversion cyanobacterium Fischerella ambigua hydrocortisone steroid |
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