Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo |
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Authors: | Detlef Weigel Hugo J Bellen Gerd Jürgens Herbert Jäckle |
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Institution: | (1) Institut für Genetik und Mikrobiologie, Universität München, Maria-Ward-Straß e la, D-8000 München 19, Germany;(2) Biozentrum der Universität, Klingelbergstraße 70, CH-4056 Basel, Switzerland;(3) Department of Genetics, Baylor College of Medicine, Texas Medical Center, 77030 Houston, TX, USA;(4) Present address: Division of Biology, California Institute of Technology, 91125 Pasadena, CA, USA |
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Abstract: | Summary The homeotic gene fork head (fkh) of Drosophila melanogaster promotes terminal as opposed to segmental development in the ectodermal parts of the gut. Molecular analysis revealed that fkh expression is not restricted to the ectodermal parts of the gut, but is detectable in a variety of other tissues. Therefore, the phenotype of fkh mutant embryos was re-examined using molecular probes as tissue specific markers. With the exception of the nervous system, which was not studied, phenotypic effects were found in all tissues expressing fkh protein in the wild-type. Particularly, these tissues include all components of the gut in the Drosophila embryo: the foregut and hindgut, the midgut and the yolk nuclei. The defects observed in the gut of fkh mutant embryos are primordium specific. |
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Keywords: | Drosophila embryo Homeotic genes Fork head gene Gut development Enhancer detection |
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