Decreased binding capacity (B
max) of muscarinic acetylcholine receptors in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD) |
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Authors: | Jessica Johansson Magnus Landgren Elisabeth Fernell Tommy Lewander Nikolaos Venizelos |
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Institution: | 1. Department of Clinical Medicine, School of Health and Medical Sciences, ?rebro University, 701 82, ?rebro, Sweden 2. Unit of Neurodevelopmental Disorders, Department of Paediatrics, Skaraborg Hospital, 542 24, Mariestad, Sweden 3. The Research and Development Centre, Skaraborg Hospital, 541 85, Sk?vde, Sweden 4. The Gillberg Neuoropsychiatry Centre, Sahlgrenska Academy, Gothenburg, Sweden 5. Department of Neuroscience, Psychiatry, Uppsala University Hospital, 750 17, Uppsala, Sweden
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Abstract: | Monoaminergic dysregulation is implicated in attention-deficit/hyperactivity disorder (ADHD), and methylphenidate and amphetamines are the most frequently prescribed pharmacological agents for treating ADHD. However, it has recently been proposed that the core symptoms of the disorder might be due to an imbalance between monoaminergic and cholinergic systems. In this study, we used fibroblast cell homogenates from boys with and without ADHD as an extraneural cell model to examine the cholinergic receptor density, that is, muscarinic acetylcholine receptors (mAChRs). We found that the binding capacity (B max) of 3H] Quinuclidinyl benzilate (3H-QNB) to mAChRs was decreased by almost 50 % in the children with ADHD (mean = 30.6 fmol/mg protein, SD = 25.6) in comparison with controls mean = 63.1 fmol/mg protein, SD = 20.5, p ≤ 0.01 (Student’s unpaired t test)]. The decreased B max indicates a reduced cholinergic receptor density, which might constitute a biomarker for ADHD. However, these preliminary findings need to be replicated in larger ADHD and comparison cohorts. |
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