Alkaloid formation in cell suspension cultures of Tabernaemontana divaricata after feeding of tryptamine and loganin |
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Authors: | E. Lucumi M. Luczkiewicz A. Vera D. Hallard R. van der Heijden R. Verpoorte |
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Affiliation: | (1) Division of Pharmacognosy, Leyden/Amsterdam Center for Drug Research, Leyden University, P.O. Box, 9502, 2300 RA Leyden, The Netherlands |
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Abstract: | A cell suspension culture of Tabernaemontana divaricata, that had lost alkaloid production, was still capable of producing a similar pattern of alkaloids as directly after its initiation. When fed with early precursors, such as tryptamine and loganin, 57% of the precursors was converted into indole alkaloids such as strictosidine, vallesamine, O-acetylvallesamine and voaphylline. Apparently most of the cell factory has remained stable during the many years of subculturing. Only an early step of the biosynthesis the flux seems to be diverted to other pathways. |
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Keywords: | indole alkaloids plant cell cultures precursor feeding Tabernaemontana divaricata |
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